Background: Deep brain stimulation targeting the subcallosal cingulate area (SCC-DBS) has emerged as a promising therapy for treatment-resistant depression (TRD). However, only half to two thirds of patients experience meaningful clinical response, …
Background: The subcallosal cingulate gyrus (SCG) is integral to cognitive function and mood regulation. Open-label SCG deep brain stimulation (DBS) studies demonstrate improvement or stabilisation of cognitive function in treatment-resistant …
This analysis aimed to (a) explore whether baseline cognitive measures could predict response to Deep Brain Stimulation (DBS) of the subcallosal cingulate gyrus for treatment-resistant depression (TRD), and (b) compare neurocognitive performance prior to and 12 months after DBS implantation. These preliminary results suggest that psychomotor speed may be a useful baseline predictor of SCG DBS treatment response, and support previous suggestions that SCG DBS has no deleterious effects on cognition.