Background: Deep brain stimulation targeting the subcallosal cingulate area (SCC-DBS) has emerged as a promising therapy for treatment-resistant depression (TRD). However, only half to two thirds of patients experience meaningful clinical response, …
We examine structural brain characteristics across three diagnostic categories: at risk for serious mental illness; first-presenting episode and recurrent major depressive disorder (MDD). We investigate whether the three diagnostic groups display a …
Background: Suicidal ideation is highly prevalent in Major Depressive Disorder (MDD). However, the factors determining who will transition from ideation to attempt are not established. Emerging research points to suicide capability (SC), which …
This report from the CAN-BIND-1 study found that clinical response to the SSRI escitalopram was associated with clinical and neuroimaging correlates of reward processing.